University of Liverpool – Schools of Biomedical, Clinical and Veterinary Sciences Faculty of Health & Life Sciences
MRes (IMB) Studentship
NFkB-PARP1-nitric oxide interaction in a seizure model
University of Liverpool – Schools of Biomedical, Clinical and Veterinary Sciences
Faculty of Health & Life Sciences
A one-year MRes studentship, funded by the BBSRC integrative Mammalian Biology (IMB) scheme (http://www.liv.ac.uk/biomedsci/imb/index.htm), is available from 01 October 2010. The studentship will cover University tuition fees and a stipend of £12,800 over 12 months.
Eligibility: UK and EU citizens only.
We invite applications from graduates holding a first or upper second class Honours degree in a relevant biomedical science subject (Neuroscience or Biological/Zoological sciences or Bio-Vets) or who expect to achieve the same in summer 2010. The successful applicant will be registered on the MRes course in the School of Biomedical Sciences which coordinates the taught components of the course. The course handbook can be downloaded from: http://www.liv.ac.uk/biomedsci/postgraduate/mres/index.htm
The research project component of the Masters programme will be jointly supervised by Dr T Thippeswamy (School of Veterinary Science) and Dr G Sills (School of Clinical Sciences).
Project summary: Nuclear Factor kappa B (NFkB) is a highly regulated transcription factor known to be involved in endogenous neuroprotective pathways in the central nervous system. This project aims to characterise the role of NFkB and other intracellular modulators of neuronal survival in susceptibility to the development of recurrent seizures in a kainate model of epilepsy. Kainate-induced seizures increase nitric oxide (NO) production, which is, in turn, known to enhance poly (ADP-ribose) polymerase 1 (PARP1) activation, potentially resulting in cell death. The interplay between NFkB, NO and PARP1 may modulate seizures. Therefore, identification of signalling proteins involved in seizure susceptibility may open up novel avenues for drug development in the epilepsy field.
Application: Please send a CV (include at least two referees) with a cover letter of personal statement to Dr T Thippeswamy by e-mail (tswamy@liv.ac.uk)
Closing date: 25 July 2010
Interview date: 28 July 2010
Filed Under: Agriculture and Food Technology • University of Liverpool
